解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The urinary excretion rates of nitrate (NO3) and nitrite (NO2) were monitored in 14 patients with active ulcerative colitis during treatment using hydrocortisone and sulfasalazine. During the active phase of the disease, the NO3 excretion was significantly higher in the patients than in healthy controls (n = 6, p < 0....
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000201332
更新日期:1996-01-01 00:00:00
abstract::The clinical value of the tumor marker human chorionic gonadotropin-beta (hCG-beta) in ascitic fluid for the differentiation of malignancy-related and non-malignant ascites was evaluated. Ascitic fluid protein, cholesterol and cytological examination were determined for comparison. Thirty-six patients with malignancy-...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000201324
更新日期:1996-01-01 00:00:00
abstract::We consider the multiple interacting factors which lead to the proliferation of human gastric enterochromaffin-like (ECL) cells, and control of this proliferation by somatostatin and its analogues. Somatostatin receptors occur in human fundic mucosa, and octreotide can be considered a useful therapeutic tool to contro...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000201386
更新日期:1996-01-01 00:00:00
abstract::Compared with other imaging modalities and clinical investigation, the 111In-pentetreotide scan identified additional metastatic disease sites in 12 carcinoid patients and 2 occult primaries, and influenced the therapeutic outcome in 36 patients [29 carcinoids, 2 atypical carcinoids, 3 cancers of unknown primaries (CU...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000201396
更新日期:1996-01-01 00:00:00
abstract::We evaluated a hand-held scintillation detector for intra-operative localisation of somatostatin-receptor-positive tumours in situ, and after excision, as an addition to preoperative scintigraphy with [111In-DTPA-Phe1]octreotide. Using the hand-held detector, the suspect tumour/normal tissue ratio R(in situ) between m...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000201406
更新日期:1996-01-01 00:00:00
abstract::The alpha-glucosidase inhibitor voglibose (AO-128) was designed to prevent rapid postprandial blood glucose rises in non-insulin-dependent diabetics. We analyzed its effect on the entero-insular axis in 72 healthy volunteers in a double-blind study design before, after the 1st dose, and on the 7th day of a 7-day treat...
journal_title:Digestion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000201282
更新日期:1995-01-01 00:00:00
abstract::Transforming growth factor-beta 1 (TGF-beta 1) is a multifunctional cytokine which modifies tissue stromal matrix synthesis, cell proliferation and immune function. In the present study, we have used a mouse monoclonal antibody to the latent (intracytoplasmic) form of TGF-beta 1 to compare its expression in 144 cases ...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000201249
更新日期:1995-01-01 00:00:00
abstract::The esophageal epithelium maintains its integrity by both structural and functional epithelial defenses. Structural components are cell membranes and intercellular junctional complexes. Functional components are cellular defenses against acidification consisting of intracellular buffering by basic proteins and bicarbo...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000201301
更新日期:1995-01-01 00:00:00
abstract::To assess the feasibility of a prospective incidence study of inflammatory bowel disease (IBD), the registration methods and incidence figures during 1990 were evaluated. The study was a collaboration between 14 hospitals in an area of close to one million inhabitants. Common diagnostic criteria for ulcerative colitis...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000201262
更新日期:1995-01-01 00:00:00
abstract::We previously reported that numerous macrophages which phagocytosed dextran sulfate sodium were observed to have accumulated in the mucosal lesions and in the spleen in experimental ulcerative colitis induced in mice with dextran sulfate sodium. In this paper, we investigated the bacterial phagocytic ability of macrop...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000201236
更新日期:1995-01-01 00:00:00
abstract::One to four months after implantation of a gastric fistula, a circadian rhythm in gastric acidity could be demonstrated by use of the intragastric 24-hour pH-metry in dogs with the gastric fistula protruding on the left side of the upper abdomen. This circadian rhythm was found to be fully developed within 3 years, an...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000201219
更新日期:1995-01-01 00:00:00
abstract::The purpose of this study was to determine the regulation of pancreatic polypeptide (PP) release by using pirenzepine (a specific M1 muscarinic receptor antagonist), 4-diphenylacetoxy-N-methylpiperidine methobromide (4-DAMP, a specific M3 muscarinic receptor antagonist), atropine (a nonspecific muscarinic receptor ant...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000201168
更新日期:1994-01-01 00:00:00
abstract::The treatment of malignant neuroendocrine gut and pancreatic tumors provides a therapeutic challenge. Surgery as well as medical treatment rarely cure the patient at this stage. Symptoms related to secretory products from the tumor might be life-threatening or at least reduce the quality of life considerably. Interfer...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000201204
更新日期:1994-01-01 00:00:00
abstract::Autonomic hyperactivity with increased cardiac output and other manifestations occurs in patients with both cirrhosis and noncirrhotic portal hypertension. The role of the disordered hepatic autonomic innervation in the mediation of these abnormalities is unknown. We have studied the hepatic nerve network and associat...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000201156
更新日期:1994-01-01 00:00:00
abstract::Biliopancreatic bypass (BPB), a bariatric surgical procedure, leads to a malnutrition-induced general visceral atrophy except for the pancreas. This work investigates the implication of cholecystokinin (CCK) in the exocrine pancreatic adaptive process using a plasma CCK assay and the CCK receptor antagonist CR 1409. N...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000201149
更新日期:1994-01-01 00:00:00
abstract::We have followed the time-course of the morphological and functional recovery of intestinal mucosa after 90 min of mesenteric vascular occlusion. At the end of the ischemic period the villi were smashed, but crypts were preserved. Microvillous hydrolase activities showed a dramatic drop when compared with sham-operate...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000201143
更新日期:1994-01-01 00:00:00
abstract::The aim of this study was to evaluate the serum behavior of human pancreas-specific protein/procarboxypeptidase B (hPASP/PCPB) in the early phases of acute pancreatitis, and to calculate its sensitivity and specificity in comparison with those of serum amylase and lipase in the diagnosis of this illness. Twenty-six ac...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000201128
更新日期:1994-01-01 00:00:00
abstract::Pharmacological management of acute variceal hemorrhage appears to be effective in patients with liver cirrhosis. Somatostatin and presumably its longer-acting analog, octreotide, are more efficient and safer than other vasoconstrictors like vasopressin, terlipressin or their combination with nitroglycerin. Drug treat...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000201115
更新日期:1994-01-01 00:00:00
abstract::Surgery is the only potentially curative treatment for patients with carcinoid tumors. Patients with localized disease even with lymph node metastases can be resected for potential cure. Patients with distant metastatic disease have been reported to be cured by resection of all tumor. However, long-term follow-up of t...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000201209
更新日期:1994-01-01 00:00:00
abstract::Proctitis and proctosigmoiditis may be distinct clinical entities. The lesions are restricted to the rectum or extend proximally to involve the sigmoid colon, respectively. Barium enema examination should be normal proximal to the rectum and sigmoid colon. Histology is used merely to confirm the disease process. We pr...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000201013
更新日期:1993-01-01 00:00:00
abstract::In rats we studied the effects of lactoferrin on experimental acute pancreatitis caused by a single subcutaneous injection of 100 micrograms/kg body weight of caerulein. Lactoferrin isolated from human milk was given intraperitoneally to rats immediately after the injection of caerulein. The injection of 100 mg/kg bod...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000201018
更新日期:1993-01-01 00:00:00
abstract::The activities of pancreatic enzymes decrease during their passage from the duodenum to the terminal ileum, but degradation rates of individual enzymes are different. Whereas lipase activity is lost most rapidly, proteases and amylase are more stable. The mechanism by which lipase activity is destroyed is proteolysis,...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000201097
更新日期:1993-01-01 00:00:00
abstract::Somatostatin is widely distributed throughout the human gastrointestinal system. There it is found in neurons and fibers of both the submucosal and the myenteric plexus and the pancreas as well as in the D cells of the stomach, gut and pancreatic islets. Whereas in the intestinal nervous system, in the duodenum and th...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000201070
更新日期:1993-01-01 00:00:00
abstract::Since arginine can stimulate lymphocyte proliferation in the healthy human, its effect on lymphocyte proliferation in vitro was studied in 7 patients with far advanced gastric cancer. These patients with normal nourishment were ambulatory and could consume a regular diet. A daily dietary supplement of 30 g arginine fo...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000201023
更新日期:1993-01-01 00:00:00
abstract::25 missionaries working in Taiwan, Thailand, Indonesia and the Philippines completed questionnaires regarding their clinical practice during the year 1980. Data were collected on the numbers of both gastric and colorectal cancers diagnosed. More than 90,000 out-patients were reviewed, and over 25,000 in-patients treat...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000201034
更新日期:1993-01-01 00:00:00
abstract::The potential therapeutic applications of somatostatin and octreotide in gastroenterology involve gut neuro-endocrine tumours, bleeding varices, bleeding peptic ulcers, gastro-intestinal fistulae, pancreatic fistulae, dumping syndrome, pancreatic pseudocysts, short bowel syndrome, acute pancreatitis, AIDS-related diar...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000201079
更新日期:1993-01-01 00:00:00
abstract::Discussion over the role of enzyme therapy in patients with acute pancreatitis is based upon theoretical considerations rather than hard data. In this respect, it differs little from most other treatments used in the management of acute pancreatitis, although, in the case of enzyme treatment, the lack of data results ...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000201102
更新日期:1993-01-01 00:00:00
abstract::We demonstrate that, in patients taking non-steroidal anti-inflammatory drugs (NSAIDs), there is inhibition of the proliferation of mucosal cells that normally leads to healing of duodenal ulcers. A microdissection technique was used to quantitate mitosis in duodenal crypts at the ulcer edge, giving a regeneration ind...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200987
更新日期:1992-01-01 00:00:00
abstract::The effects of two recently developed gastrin receptor antagonists, PD 136450 and L-365,260, on pentagastrin-stimulated acid secretion were investigated in rats. PD 136450 at a dose of 6 mg/kg s.c. (9.6 mumol) completely abolished acid secretion induced by pentagastrin. The inhibition of 18 mg/kg PD 136450 s.c. lasted...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200993
更新日期:1992-01-01 00:00:00
abstract::Recent studies have been reviewed to establish the possible importance of the interaction between Helicobacter pylori infection and gastric acid secretion. H. pylori infection results in increased gastrin release, but this does not lead to gastric acid hypersecretion and gastrin normalizes after eradication of the inf...
journal_title:Digestion
pub_type: 杂志文章,评审
doi:10.1159/000200908
更新日期:1992-01-01 00:00:00
abstract::Omeprazole was administered for up to 6 years in 859 patients for 'prevention of relapse in patients with poorly responsive peptic ulcer or reflux oesophagitis'. The pattern of adverse events reported during long-term treatment was similar to the adverse-event profile in short-term treatment with omeprazole (n = 2,818...
journal_title:Digestion
pub_type: 杂志文章,meta分析
doi:10.1159/000200922
更新日期:1992-01-01 00:00:00
abstract::The gastrin response to a low and a high dose of gastrin-releasing peptide infusion was studied in healthy volunteers and in patients with duodenal ulcer disease. In duodenal ulcer patients, the gastrin response was exaggerated. Cholinergic blockade did not change the gastrin release in healthy volunteers. Antrum dist...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200869
更新日期:1992-01-01 00:00:00
abstract::We studied the functional coupling between antral somatostatin and gastrin cells in pigs using isolated perfused preparations of the antrum with intact supply of the vagus nerves. Luminal acidification significantly inhibited gastrin secretion to 61 +/- 3% of basal secretion and increased somatostatin output 9-fold. I...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200882
更新日期:1992-01-01 00:00:00
abstract::Life events and daily stress were assessed in patients with duodenal ulcer, active or in remission, and in matched disease and normal controls. The mean positive life event scores were significantly lower in duodenal ulcer patients than in disease and healthy controls, and lower in patients with active ulcer than in t...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200949
更新日期:1992-01-01 00:00:00
abstract::The case of a 52-year-old male with chronic active type B hepatitis in whom severe exacerbation of liver disease was associated with interferon alpha treatment is described. It seems that patients with very active forms of chronic hepatitis B may experience severe and symptomatic exacerbation of liver disease during i...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200940
更新日期:1992-01-01 00:00:00
abstract::Functional changes of the exocrine pancreas in cerulein-induced pancreatitis were evaluated with the isolated perfused rat pancreas. In control specimens (n = 7), baseline pancreatic juice volume was 0.23 +/- 0.06 microliter/min and after stimulation with CCK-8 (10(-10) M) and secretin (10(-10) M), it was 2.26 +/- 0.4...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200879
更新日期:1992-01-01 00:00:00
abstract::The effects of gastric fundectomy and antrectomy on the colonic mucosa were studied in hamsters over 5 and 25 days. Sham-operated animals served as controls. Basal plasma gastrin concentrations were significantly increased after fundectomy and significantly decreased after antrectomy. Five days after fundectomy, there...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200968
更新日期:1992-01-01 00:00:00
abstract::Fasting reduced the weight, protein, DNA, RNA and polyamine contents of the small intestine of rats, but its effects on the in vivo uptake of intraperitoneally injected 14C-spermidine through the basolateral membrane of the small intestine were small. The uptake of putrescine was nearly doubled by fasting for 48 h. Fa...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200737
更新日期:1991-01-01 00:00:00
abstract::A hepatitis C virus (HCV) chronically infected patient developed an episode of acute hepatitis during the course of immunosuppressive therapy given for a lymphoproliferative disease. It was noted that anti-HCV antibody response, seen to be relatively stable during the follow-up, lowered dramatically in coincidence wit...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200740
更新日期:1991-01-01 00:00:00
abstract::Intact segments of rat ileum were stimulated in vitro by either electrical field stimulation (EFS) or cholinergic stimulation with carbachol, in the presence of absence of varying insulin concentrations (50, 100 and 200 microU/ml), and the contraction in the longitudinal axis was recorded. Insulin had no significant i...
journal_title:Digestion
pub_type: 杂志文章
doi:10.1159/000200694
更新日期:1991-01-01 00:00:00